Fibromyalgia is a neuropathic origin pain that has been shown to follow the central sensitization paradigms. Philippe Berenger, MD, a pain management specialist at Cleveland Clinic defines fibromyalgia as being more widely accepted as a ‘primary neurogenic disease’. This fits with the descriptions of pain originating from the CNS (central nervous system). Providers should be aware that treatments such as mind-body awareness exercises, yoga, acupuncture, massage and chiropractic are all known to produce varying levels of endorphin release and CNS regulation of pain; that show promise with most forms of centrally sensitized pain syndromes, such as fibromyalgia.